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Research Sample Repository

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Research Sample Repository Protocol and Consent Forms

The Research Sample Repository contains cell and serum samples collected from related and unrelated transplant donors, cord blood units and recipients.

Research goals

The primary objective of the Research Sample Repository is to make these samples available for research studies related to histocompatibility and hematopoietic cell transplantation (HCT).

These data may be used in research to:

  • Improve the understanding of tissue matching for HCT donors and recipients
  • Determine and evaluate the factors that affect HCT outcomes
  • Study the distribution of HLA tissue types in different populations

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Recipient and donor participation

The Research Sample Repository includes cell and serum samples from allogeneic related and unrelated donors and recipients. The protocol also allows for submission of research samples from registered donors with rare tissue types. Complete eligibility requirements are outlined in the study protocol.

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IRB requirements

U.S. transplant centers

To be compliant with United States Federal Regulations for human research subject protection, U.S. transplant centers must obtain IRB-approved informed consent from recipients before submitting samples to the Research Sample Repository.

Although all NMDP/Be The Match centers participate in the Research Sample Repository protocol, only select NMDP/Be The Match centers currently submit related recipient and donor samples. In the future, additional NMDP/Be The Match centers may be invited to submit related recipient and donor samples.

If your center only performs related donor HCT and/or autologous HCT, you will not submit research samples, and therefore do not need to obtain local IRB approval for the Research Sample Repository protocol.

Upon obtaining local IRB approval, the NMDP/Be The Match IRB Office must receive a copy of the local IRB’s approval letter, approved protocol and informed consent documents. These documents should be sent to:

Christina Jobe, Sr. Human Research Protection Program Specialist
National Marrow Donor Program/Be The Match
500 N. 5th St.
Minneapolis, MN 55401
Telephone: (763) 406-8164
Fax: (763) 406-5899

The NMDP/Be The Match IRB Office tracks the IRB approval for the Research Sample Repository at each participating center. Your center will receive a renewal reminder approximately two months in advance of the local continuing review date. Local IRB approval for this protocol must be current at all times. Failure to have current local IRB approval may affect your center’s ability to meet CPI requirements for sample submission.

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CIBMTR approved protocol and consent forms

The CIBMTR, through the NMDP/Be The Match IRB, has approved the following protocol and consent forms. Your center must submit these documents to your local IRB for review and approval. CIBMTR and NMDP/Be The Match allow the consent forms to be formatted according to each site’s requirements, but requires the protocols to be submitted as written.

Repository protocol

Repository IRB approvals

Repository recipient consent forms

Allogeneic transplants

Marrow toxic injury

Repository donor consent forms

Adult allogeneic related/unrelated donor consent form

Last Updated: 8/22/2016 1:15 PM