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Steve Spellman,MBS,Scientific Director
Under the current leadership, the GVHD WC focused on:
In recent years, the GVHD WC published nine articles (four in 2014-2015, five in 2011-2013) and presented six abstracts at the ASH Annual Meeting. The committee has 11 ongoing studies with plans of completing at least 3 studies in each academic year, making it one of the most efficient and productive committees around. The GVHD WC benefits from broad enrollment in the CIBMTR Research Database. The number of allogeneic transplants from 2001-2014 total more than 37,000 for leukemic diseases (acute myeloid leukemia, acute lymphoblastic leukemia, myelodysplastic syndrome, chronic myeloid leukemia, and other leukemia) and more than 15,000 for non-leukemia malignancies. To ensure that the CIBMTR Research Database will continue to capture relevant GVHD data, the Working Committee leadership participated in the revision of the data collection forms for implementation in 2016. The changes will allow capture of new GVHD prophylaxis strategies; relevant dates of acute GVHD onset and maximum grade on the TED forms, rather than on just the CRF-level forms; and NIH organ scoring criteria for chronic GVHD.
Since 2014, the PCWC has published five manuscripts, including one in Blood, two in Pediatric Blood and Cancer, and two in Biology of Blood and Marrow Transplantation. These abstracts were also presented at various national and international meetings prior to publication. The PCWC has four ongoing studies addressing important topics, such as the role of autologous HCT for Wilms’ tumor, trends in pediatric transplant, personalized prognostic information for pediatric leukemia survivors, and outcomes of second transplant for relapsed malignancy.
One of the unique features of PCWC is our recent focus on the involvement of fellows and junior faculty on new studies. We have been able to engage two enthusiastic fellows on one of our current studies, and the whole experience has been mutually rewarding. We plan to continue this tradition and will be proactively contacting and inviting fellows and junior faculty members to participate in each of the upcoming studies. We believe this early involvement will encourage long-term participation of young investigators in PCWC activities in the future.
The CIT (CIBMTR Information Technologies) Program Management team consists of two Program Managers, four Project Managers, one Project Coordinator, and four Business System Analysts. The Minneapolis team is led by Senior Program Manager, Katherine Gee, and the Milwaukee Team is led by Program / IS Manager, Tom Moerke.
Left to Right: Tom Moerke, Andrew Davidson
Front Row (left to right): Shawn Freeman, Katherine Gee, Ericka Wheeler
Back Row: Dean Kloker, Sharon Ewer, Dan Campbell, Karen O'Connor, Bridget Wakaruk, Ashley Pull
There are 11 BMT CTN trials released to centers or open to accrual. The four open to additional center participation are indicated with purple font.
To get up-to-date information about BMT CTN studies, meetings, and news:
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The Advisory Committee, made up of members from across the globe, maintains careful oversight of the CIBMTR research agenda. The 2016 committee members are listed on the CIBMTR website, and we are pleased to welcome the newest members of the committee:
The CIBMTR is supported by Public Health Service Grant / Cooperative Agreement 5U24CA076518 from the NCI, NHLBI, and NIAID; a Grant / Cooperative Agreement 5U10HL069294 from NHLBI and NCI; a contract HHSH250201200016C with HRSA / DHHS; two Grants N00014-15-1-0848 and N00014-16-1-2020 from the Office of Naval Research; and grants from our corporate and private contributors, which are listed on the CIBMTR website.
Need an acronym defined? Review our list of common abbreviations.