The Bioinformatics Research Program provides expertise in, and conducts research on, translational and operational bioinformatics.
The program is currently engaged in projects to:
- Develop pipelines to analyze Next Generation Sequencing typing data, including full-gene human leukocyte antigen (HLA), killer-cell immunoglobulin-like receptor (KIR), and genome-wide sequencing, to refine our understanding of genetic matching
- Investigate the role of genetic ancestry in transplantation, including the best way to match individuals with multiple races in their family tree
- Develop data standards and tools for making immunogenetic data portable for research and clinical use
- Investigate HLA data from other countries to better understand global frequencies and improve matching
- Develop methods for HLA association studies
2015 Completed Studies
| Estimating demand and unmet need for allogeneic hematopoietic cell transplantation in the United States using geographic information systems |
Published |
| Power laws for heavy-tailed distributions: modeling allele and haplotype diversity for the National Marrow Donor Program |
Published |
| Progress toward curing HIV infection with hematopoietic cell transplantation |
Published |
| Race, ethnicity and ancestry in unrelated transplant matching for the National Marrow Donor Program: a comparison of multiple forms of self-identification with genetics |
Published |
| On modleing HLA-identical sibling match probability for alloHCT: estimating the need for an unrelated donor source |
Published |
| Asymmetric linkage disequilibrium: tools for assessing multiallelic LD |
Published |
| Minimum information for reporting next generation sequence genotyping (MIRING): guidelines for reporting HLA and KIR genotyping via next generation sequencing |
Published |
| Banking or bankrupting: strategies for sustaining the economic future of public cord blood banks |
Published |
For further information, contact:
Martin Maiers
Director of Bioinformatics
Phone: (612) 627-5892
