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Bioinformatics Research

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 Bioinformatics Research Program

​The Bioinformatics Research Program provides expertise in, and conducts research on, translational and operational bioinformatics.

The program is currently engaged in projects to:
  • Develop pipelines to analyze Next Generation Sequencing typing data, including full-gene human leukocyte antigen (HLA), killer-cell immunoglobulin-like receptor (KIR), and genome-wide sequencing, to refine our understanding of genetic matching
  • Investigate the role of genetic ancestry in transplantation, including the best way to match individuals with multiple races in their family tree
  • Develop data standards and tools for making immunogenetic data portable for research and clinical use
  • Investigate HLA data from other countries to better understand global frequencies and improve matching
  • Develop methods for HLA association studies

2015 Completed Studies

Title Status
Estimating demand and unmet need for allogeneic hematopoietic cell transplantation in the United States using geographic information systems Published
Power laws for heavy-tailed distributions: modeling allele and haplotype diversity for the National Marrow Donor Program Published
Progress toward curing HIV infection with hematopoietic cell transplantation Published
Race, ethnicity and ancestry in unrelated transplant matching for the National Marrow Donor Program: a comparison of multiple forms of self-identification with genetics Published
On modleing HLA-identical sibling match probability for alloHCT: estimating the need for an unrelated donor source Published
Asymmetric linkage disequilibrium: tools for assessing multiallelic LD Published
Minimum information for reporting next generation sequence genotyping (MIRING): guidelines for reporting HLA and KIR genotyping via next generation sequencing Published
​Banking or bankrupting: strategies for sustaining the economic future of public cord blood banks Published
​7/8 and 9/10 or better high resolution match rate for the Be The Match Unrelated Donor Registry Published​
For further information, contact:
Martin Maiers
Director of Bioinformatics
Phone: (612) 627-5892

Last Updated: 4/20/2016 10:48 AM